Finding her strength: Fitness coach Danica Doble shares in her own words

Danica Doble, a fitness coach and content creator who has been living with type 1 diabetes (T1D) since 2009 recently partnered with Breakthrough T1D Canada as a social media ambassador. She sat down with the organization to share more about her journey, and why she’s so open about how teenage struggles living with T1D empowered her to become a fitness trainer and passionate advocate for the T1D community.

Content warning: please note this piece discusses eating disorders

What do you remember about your T1D diagnosis?

I remember being a seven-year-old little girl and experiencing all of the vicious symptoms that come along with a type 1 diabetes diagnosis. It was a Monday night, and I was at gymnastics practice. Immediately after practice, my mom got a phone call from my doctor stating that I needed to go to the hospital because I had just been diagnosed with T1D. For the next five days, I spent eight hours in the hospital each day and my parents learned everything they could about T1D. Back in 2009, type one diabetes wasn’t talked about much, so my parents really didn’t know what to expect. I remember playing with all the toys that they provided in the hospital and thank goodness for my parents for being attentive, because I most definitely was not. I returned to normal life after those five days, not knowing what was happening to me, not knowing why my parents had to poke my finger and poke my arm every time I wanted to eat. However, as hard as that week was, that week is the reason that I’m who I am today.

Can you tell us a little about starting your fitness journey, after being an active teenager with T1D?

My fitness journey began in 2018; I was like every other teenager. I played sports. I hung out with my friends. I went to school. To be honest with you, I probably lived too much of a normal life. I neglected my blood sugars throughout my teen years and was definitely not focussed on diabetes management. I partied a little too much at times and had a little too much fun with my friends, however, I definitely don’t regret anything because not only did I experience life, but it also prompted me to start my fitness journey.

Although I was quite active as a competitive soccer player, my nutrition was really something that I neglected. After my trip to Europe in 2018, I had told myself that I just wanted to lose 5 pounds to feel better about myself. I quickly learned about calorie deficits and strength training and began doing things to an extreme. 5 pounds later turned into 50. During this time, I had not only lost too much weight but had also lost my period and had developed two eating disorders. It was at this point that I decided to become the healthiest and strongest version of myself. I put on about 20 to 30 pounds, much of it being muscle, and learned everything you could about working out and nutrition.

Can you share a little about your dual diagnoses and how you manage your binge eating disorder (BED) today

My binge eating lasted for about two years, and it was due to the fact that I had eaten so few calories for so long. There were many days when I felt so out of control with my eating and I would compensate these binges by doing hours worth of cardio the next day. It’s an incredibly vicious cycle and very, very difficult to get out of. After my binges, my blood sugars would be so incredibly high, and it would take them hours if not days to come down then the cycle would repeat itself. Today, I am proud to say that I have been free for five years. I started fueling my body properly and made sure that I was getting enough calories. Although I still struggle at times with overeating I no longer eat until I feel sick, which in my opinion is major progress.

How did you come to have food neutrality?
My relationship with food has been rocky over the years, but I am proud to say that my relationship with food is at an all-time high. I now understand that there are no good or bad foods and food is food. Some foods are more nutrient dense while other foods are less nutrient dense. However, that does not make one better over the other. Sometimes my body craves a chocolate cake while other times my body is craving a bowl of fruit. In my opinion, I believe that all food serves a significant purpose whether it’s food that makes your body feel good, or food that makes your soul feel good. While the way I physically feel matters, so do memories. I’ve come to realize that food will always be a massive part of celebrations and events, and when I’m 80 years old, I want to be able to look back on these memories and remember all of the laughs that were shared over good food, not how little I ate that day or how healthy I was during these events.

How does powerlifting help you feel empowered with managing your T1D, both physically and emotionally?

Weightlifting has done wonders for me not just physically, but emotionally too. Not only has it significantly helped my blood sugars, but it helped me in so many other aspects of my life. The empowerment I feel from weightlifting is like no other because it just really goes to show that you can do absolutely anything in your life, even with type 1 diabetes.

How do you use your social media platforms to connect with others in the T1D community

I started my social media platforms in 2022 to mainly focus on the fitness side of things however, after about a year, I wanted to do more. I wanted to make an impact for the T1D community and show people that living with it can have positives. I started my type one diabetes account by posting relatable content and bringing light to dark topics quickly. I was able to grow a substantial following on that account and created a community like no other! I’ve connected with hundreds, if not, thousands of people and it is something I will forever be grateful for. I get tons of messages from people telling me that I’ve helped them, when in reality they’ve helped me just as much.

What are you excited about partnering with Breakthrough T1D Canada?

I’m excited to partner with Breakthrough T1D Canada because of the incredible impact the organization has on the type 1 community. I believe that it’s so important to hear stories and experiences from other type 1s, so people know they’re not alone in their experience & journey.

Anything else you’d like to share with the Canadian T1D community?

I’d like to share with the community that as much as diabetes can suck sometimes, and be incredibly difficult, perspective is everything. Type 1 diabetes has connected me with so many amazing people, and it’s made me strong, courageous, and powerful!

Follow Danica on her IG account @deeabetes

Give to Gain this International Women’s Day 

Sunday, March 8 is International Women’s Day (IWD), celebrated globally and this year recognizing its 115 anniversary. On IWD we are asked to imagine a world that is truly equal. For that to happen, we need a world free of bias, stereotypes, and discrimination. A world that’s diverse, equitable, and inclusive. A world where difference is not only recognized but also valued and celebrated. 

The theme for IWD 2026 is ‘Give To Gain’.  Because, when we give, we gain. 

The IWD 2026 Give To Gain Campaign encourages a mindset of generosity and collaboration and emphasizes the power of reciprocity and support. When people, organizations, and communities give generously, opportunities and support for women increase. Giving is not a subtraction, it’s intentional multiplication. When women thrive, we all rise. 

This theme resonates deeply with Breakthrough T1D Canada, an organization with humble grassroots beginnings, started in the basement of type 1 diabetes (T1D) families desperate to find a cure for their children, but also to raise awareness of what living with this disease is truly like. 

From our beginning, we have both supported women, but even more, have been supported by women. From the mothers who demanded more for their children, and their daughters who became some of the T1D community’s fiercest advocates, and who continue to do so today.  

To our researchers, many of whom are women, and who continue down the path laid by trailblazing women like Dr. Priscilla White, who was an early pioneer in diabetes research and treatment. Dr. Dorothy C. Hodgkin who first discovered the three-dimensional structure of insulin, Dr. Helen M. Free, who along with her husband created Clinistix, allowing people to check their glucose at home, a significant advance in disease management.  

These women played an essential role in advancing understanding of T1D, and the dozens of women researchers we are proud to support today continue this legacy, leading their own critical projects that improve living with T1D and driving us closer to cures. Women researchers can be found in all areas of T1D research, including precision medicine, cell therapy, screening and prevention, disease-modifying therapies, reproductive health and mental health. 

Breakthrough T1D also supports a number of women fellows and post-docs, who are leading the next generation of researchers in all areas of T1D research.   

To our donors, supporters, volunteers and partners who give tirelessly and selflessly so that these researchers can continue their critical work and get us closer to a world free from T1D. Who with all they give, allow other women to thrive in their field and gain the knowledge needed to make living with T1D safer and better today, while they work towards cures for tomorrow. 

To our women-led organization, who are entrusted with the responsibility of stewarding that support with consideration and care.  

We have come a long way since the first International Women’s Day 115 years ago, but there is still so much more work to be done. Breakthrough T1D Canada renews our commitment to ‘Give To Gain’ and continue the important work of creating a gender equal world.

Breakthrough T1D Canada is pleased to announce three new trainees in partnership with the Canadian Islet Research and Training Network 

Breakthrough T1D Canada is excited to continue its successful partnership with the Canadian Islet Research and Training Network (CIRTN) and announce a fourth cohort of co-funded trainees beginning in 2026. 

CIRTN was established in 2020 as a world-class training and research network with joint contributions from the University of Alberta, University of British Columbia, University of Manitoba, Université de Montréal, Institut de Recherches Cliniques de Montréal, and the University of Toronto and now includes 12 institutions from across Canada.   

Breakthrough T1D Canada has partnered with CIRTN to leverage funding to this network from the National Science and Engineering Research Council – Collaborative Research and Training Experience (NSERC-CREATE) program.  

Previous cohorts: 

2023 

2024 

2025 

Dr. Austin Miller –Postdoctoral Fellow (supervisor: Francis Lynn, University of British Columbia) 
Improving the ability to generate stem cell-derived pancreatic islets in the lab 
Regenerative medicine approaches are being developed as an alternative in which pancreatic islets are transplanted into patients to restore autonomous insulin secretion, reducing the patient burden of T1D management. Stem cell-derived pancreatic islets (stem cell islets) have the potential to provide an unlimited supply of islets for transplantation.  

Overall, my research aims to improve our ability to generate stem cell-derived islets in the lab. I will develop tools to study cellular pathways that allow cells to manage the burden of secreting proteins like insulin and perform studies to better understand the role of these pathways in the generation of insulin-secreting cells. These findings will inform strategies to further improve the efficiency of stem cell-derived islet generation. 

Dr. Chris Schaaf – Postdoctoral Fellow (supervisor: Patrick MacDonald, University of Alberta)  
Standardizing stem cell-derived beta cells 
The advent of stem cells has provided a promising approach towards generating a functional cure for type 1 diabetes. However, current protocols do not generate stem cell-derived beta cells that appropriately produce and regulate insulin secretion, and there is a lack of standardized assays, benchmarks, and analytical tools for comparing stem cell-derived beta cells to human donor islets. 

This project will leverage the humanislets.com dataset – a collection of ‘gold standard’ molecular and functional datasets from hundreds of human organ donors – funded by Breakthrough T1D and CIHR.  Using this robust dataset and collaborative expertise in computation and artificial intelligence, we will perform comparative analyses and benchmarking for the improvement of stem cell-derived beta cell outcomes. This will enable us to develop benchmarking standards and protocols that can be used by researchers anywhere in the world to compare their own lab generated  stem cell-derived beta cells to our repository of human donor islets data, and use that data to generate  stem cell-derived beta cells that truly mimic the function of human beta cells. 

Yihan Luo – PhD student (supervisor: Kacey Prentice, University of Toronto)  
A new approach to prevent type 1 diabetes by strengthening insulin producing cells 
In the human body, organs communicate with each other through hormones, such as insulin, made by beta cells in the pancreas. Insulin tells fat, muscle, and liver cells to absorb sugar from the blood, which provides energy and keeps blood sugar levels in balance. In type 1 diabetes (T1D), the immune system destroys beta cells, causing lifelong insulin deficiency. Evidence suggests that T1D begins before beta cell loss, due to disrupted insulin responses and organ–pancreas communication. Fabkin, a hormone complex secreted by fat, affects beta cell health and research has shown that blocking it in mice helped beta cells stay healthier. Our project studies Fabkin’s key component, NDPK, to learn how it affects beta cell survival and function, and test whether NDPK-targeting drugs can prevent or delay T1D. If successful, this work could lay the foundation for a new approach to prevent T1D by protecting beta cells before they are damaged or lost. 

In her own words: Stephanie Atkinson

Stephanie Atkinson, a Montreal, QC based adult Breakthrough T1D Canada ambassador, sat down with the organization to discuss what drew her to volunteering and what it’s like to be diagnosed as a busy mother and businesswoman.

Tell us a little bit more about yourself

My name is Stephanie Atkinson. I’m a mom of four, a skin and beauty expert, founder of Mayfield Glow, and a recent finalist on the Miss Universe Canada stage.

Before anything else, I’m someone who has learned firsthand how fragile life can be — and how powerful resilience is.

I built my career helping women feel confident and cared for through skincare and wellness. But my own health journey shifted my purpose in a deeper way.

Standing on the Miss Universe Canada stage as one of the first finalists openly wearing two visible diabetes devices — an insulin pump and a continuous glucose monitor — wasn’t just about competing. It was about representation. It was about showing that living with a chronic illness does not disqualify you from showing up fully, boldly, and beautifully in the world.

Today, I use my platform to advocate for type 1 diabetes awareness, especially for adults diagnosed later in life, while balancing motherhood, entrepreneurship, and advocacy.

Can you share a little bit about your diagnosis? What do you remember?

Before my diagnosis, I was sick for many days, but it was during COVID and most clinics were closed, so accessing care felt nearly impossible. I was exhausted in a way that didn’t make sense. I now know I was experiencing all the classic “4 Ts” of type 1 diabetes — thirst, tiredness, toilet, and thinner. I was constantly thirsty, extremely fatigued, using the bathroom nonstop, and losing weight rapidly. My vision began to blur, I could barely walk, and deep down I knew something was very wrong — but as a mom, you push through.

When I finally got into a clinic, I was told I had a urinary tract infection. I remember saying I had never had one before, but I was told that strange things happen before turning 30. I left feeling dismissed, even though my body was telling me something much more serious was happening.

The next morning, everything changed.

I woke up to a police officer at my door doing a wellness check. My doctor had reviewed my results and realized I had been misdiagnosed — my blood work showed I was actually in diabetic ketoacidosis (DKA), a life-threatening emergency where the body begins breaking down fat for fuel because it cannot use glucose properly without insulin. Acid builds up in the bloodstream, and without immediate treatment, it can be fatal.

When I got to the hospital, things were still confusing. Initially, I was diagnosed with type 2 diabetes because I was an adult. But my condition worsened quickly, and I ended up in the ICU with severe DKA. I remember feeling like my body was shutting down. I was losing vision in my left eye, I couldn’t walk properly, and everything felt overwhelming and terrifying.

Later, after further testing, I was correctly diagnosed with type 1 diabetes.

I was 29 years old, a mother, and suddenly my entire life changed. I didn’t fit the stereotype people imagine when they think of Type 1 diabetes — and that experience is one of the main reasons I advocate so strongly today, especially for adults who are diagnosed later in life.

Over 70% of Canadian T1D diagnoses are in adults. How did you find the transition to your new normal?

The hardest part wasn’t just learning how to manage insulin — it was realizing how little support exists for adults diagnosed later in life. 

As a mother and entrepreneur, I had to quickly learn how to balance blood sugars, medical appointments, and new technology while still showing up for my family and my work. There’s a lot of education and community built around children diagnosed with Type 1, but adult diagnosis can feel isolating.

To be honest, there were many times I wished I had been diagnosed as a child. By the time I was diagnosed, I was already an adult, already a mom, already carrying so many responsibilities. A lot of guilt came with that — guilt about how my diagnosis might affect my family, guilt about slowing down, and guilt about having to suddenly prioritize my health in ways I never had before.

Over time, I learned that managing diabetes isn’t selfish — it’s necessary. I built a support system, connected with community, and learned to use technology as a tool for confidence instead of fear. That transition taught me how strong and adaptable we really are, and that being diagnosed later in life doesn’t mean you’re behind — it just means your journey looks different.

You went into DKA prior to your diagnosis. Are ketone levels and how they’re measured something you think about more now?

Absolutely. Once you’ve experienced DKA, awareness becomes second nature.

I pay close attention to how my body feels, especially when blood sugars are elevated or when I’m sick. I monitor ketones when needed and rely heavily on my diabetes technology for early warnings. It’s not about living in fear — it’s about understanding my body and staying proactive so I can avoid going through that experience again.

Why do you wear your diabetes devices so visibly?

The honest answer is that at first, I didn’t want to.

In the beginning, I was ashamed of my devices and tried to hide them as much as possible. As a woman working in beauty and wellness, I felt pressure to look polished and seamless, and I worried that people would only see my diagnosis instead of me.

What changed my perspective was my children.

One day, one of my kids came home from school excitedly telling me about a student in their fifth-grade class who wore a Dexcom and was having a diabetic emergency. Because my child was familiar with diabetes from watching me manage it every day, they recognized what was happening and were able to help alert an adult quickly.

That moment shifted something in me. I realized this was bigger than me. If more people saw these devices visibly — and understood what they were — it wouldn’t just help me feel more confident, it could help others too.

On the Miss Universe Canada stage, I made a conscious decision not only to wear my devices openly, but to bedazzle them. So many times, I hear, “But you don’t look sick.” And the truth is — Type 1 diabetes is an invisible illness. I wanted to bring joy and light to something that can feel heavy and misunderstood. If I was going to wear them, I was going to wear them proudly.

Visibility creates conversation. Conversation creates understanding. And understanding saves lives.

If someone sees me and feels less alone or more confident wearing their own devices, that makes it all worth it.

Is there anything else you wanted to share with the T1D community, particularly with others diagnosed as adults?

You did not cause this.

Being diagnosed as an adult can feel confusing and isolating because many people still believe type 1 diabetes only happens in childhood. When you’re diagnosed later in life, you’re often already carrying so many responsibilities — careers, families, and expectations — and it can feel like your world shifts overnight.

But your diagnosis does not change your value, your strength, or your future.

Give yourself permission to learn slowly, to ask for help, and to prioritize your health without guilt. Managing diabetes isn’t about being perfect — it’s about showing yourself grace and continuing to move forward. 

You can still chase your dreams. You can still show up boldly. You can still build a beautiful, full life. Type 1 diabetes is something I manage — it does not define or limit who I am.

***

Breakthrough T1D Canada thanks Stephanie for her efforts on behalf of the T1D community and for her important work as a peer support volunteer and advocate.

Guest post: What does a cure for type 1 diabetes (T1D) look like?

What does a cure for type 1 diabetes (T1D) look like?

Authors: Katie Bartel, Beth Miller, Tony Lucas, Benjamin Mammon, for The Breakthrough T1D Canucks For Kids Fund Centre of Excellence at UBC T1D Lived Advisory Group

That was the question that the Type 1 Diabetes Lived Experience Advisory Group attempted to answer through a recent anonymous survey.

The group quickly learned it’s not an easy puzzle to solve.

The Breakthrough T1D Canucks For Kids Fund Centre of Excellence at UBC T1D Lived Advisory Group has a key role at Centre outreach events and enabling dialogue between researchers and people living with T1D. The recent survey was done to gather information to inform these discussions and, in turn, the Centre’s cure-focused research program.

Of the 49 respondents, there were varying degrees of what a cure for T1D looks like – some want fully functioning insulin production, whereas others would be satisfied with a device-free lifestyle. Some respondents focused more on improved quality of life, while others struggled to put any kind of description to a T1D cure.

“Type 1 requires so much decision making on a daily basis that I cannot help but wonder what my brain will do with that space and time,” one participant commented. “Am I less likely to face decision fatigue? More likely to have more resilience to frustration… the potential is significant, but the ability to guess what that might be is difficult.”

It’s these types of responses that the Centre’s T1D Advisory Group believes is essential for researchers to know.

“If we don’t know what a cure looks like for people with type 1 diabetes, we can’t work towards it,” said Dr. Søs Skovsø, scientific project coordinator at the Centre, and Chair of the Advisory Group.

And that’s where the Advisory Group plays a role.

The Advisory Group is made up of eight members who either live with T1D or care for people living with T1D. The group’s objective is to integrate the voices of people with T1D into T1D research.

The Advisory Group developed a survey that was distributed through local T1D community networks and stayed open for one month. There were 49 respondents in total; 33% were caregivers and 67% lived with T1D. Most respondents lived in Canada – 53% in BC and 41% in other provinces. The remaining 6% lived internationally.

The main query of the survey was “What does a cure for T1D mean for you?”

Questions included rating the importance of restoring the body’s ability to produce its own insulin again, versus preventing the immune system from attacking insulin-producing cells. The survey asked about the importance of a cure being device free, as well as the significance of improvements to quality of life gained with the introduction of a cure.

51% of survey respondents responded that a cure involving stem cell therapy would be extremely important; 58% rated immune therapy as extremely important; and 40% rated being device-free as extremely important. And when asked about the most important benefit that a T1D cure could provide – improved mental health was rated higher than freedom from blood sugar checks, elimination of insulin dependence, and reduction of long-term health risks.

The question that was most surprising for Advisory Group members and researchers at the Centre was how confident respondents were that a cure would be found in their lifetime.

Responses varied: some were confident, others skeptical.

“The mixed response from the community doesn’t reflect the exciting work that’s going on at the Centre,” said Advisory Group member Beth Miller. “This highlights a need for better communication between the scientific community and the broader T1D community,” Miller added.

Skovsø agrees.

“Some people have lost hope for a cure, and at the same time others thinking that there’s a cure coming next year,” she said. “This means that the research community has to do a better job at communicating that a cure may not be available next year, but it is within reach.”

The Advisory Group’s survey is the first of its kind according to Dr. Bruce Verchere, one of the lead principal investigators at the Centre.

“This survey promises to increase the impact of T1D research in the Centre by helping researchers better understand the hopes and expectations of persons living with T1D, and how research could improve their lives,” said Verchere.

“What a cure looks like to a parent of a child with T1D, or to someone living with T1D for 30 years, or to a scientist is going to be different,” said Skovsø. “Hopefully this survey will help open minds that a cure is not single-sided; it’s multi-faceted.”

This survey was just the first step. A second quantitative survey is now being developed by the Advisory Group, in collaboration with the Centre research team, with the intent of reaching a wider audience and publishing the results in a scientific journal.

“It’s cool to see the work and conversations coming out of the Advisory Group trickle and spread into the science community,” said Skovsø. By publishing a larger study, “we can spark even more conversation and understanding.”

Valentine’s Day Treat Carb Counts

Do you prefer the sweetness of a Hershey’s kiss, or maybe you like the spice of a cinnamon heart? For most of us, we can grab a handful of Valentine’s Day candy without thinking about it. But for people living with type 1 diabetes (T1D) every snack, every meal, every piece of food eaten must first be calculated for carbs and sugar against the insulin they need to take – just to stay alive.

For newly diagnosed families, learning the calculations of carbs against insulin needs can be challenging at first, but with practice and consistency this should become easier over time. And even for people who have been living with T1D for decades, the sugar or carb counts of certain foods can vary, either by brand or a change to the product.

Always make sure to check the label carefully, and consider downloading an app, like Roche’s mySugr app, Diabetes M, or apps from your device manufacturers. Visit the website of the manufacturer of your device to find out more.

Carbs and Cals lets you take a photo of your meal, and the app searches its library of over 19,000 foods to give you the nutritional information you need.

MyFitnessPal app includes a database of over 14 million foods so you can find out nutritional information about what you’re eating, including the amount of carbs. It has a handy barcode scanner for ready-made products, and you can also add your own foods.

There is a free version and a paid version which has more features. The app is compatible with iOS and Android.

We always want the holidays to be fun for you, or a loved one with T1D, knowing that treats can still safely be enjoyed. It just requires a little extra work and knowing the carb levels of  favourite candies.

Remember also to factor in the portion of candy or chocolate you or your child eats to get a more accurate carb count.

  • Great Value Cinnamon Hearts (25 pieces) contains 15g total carbs, 15g net carbs, 0g fat, 0g protein, and 60 calories.
  • Hershey Kiss (1 piece) contains 3g total carbs, 2.8g net carbs, 1.5g fat, 0.4g protein, and 27 calories.
  • Hershey’s Reese’s Peanut Butter Cup (1 package – each 1.5 OZ – 2 cups – 2 1/8″ diameter per cup) contains 23g total carbs, 21.7g net carbs, 12.8g fat, 4.3g protein, and 216 calories.
  • Jellybeans (10 piece) contains 28g total carbs, 28g net carbs, 0g fat, 0g protein, and 113 calories
  • Compliments Jujubes (8 candies) contains 33g total carbs, 33g net carbs, 0g fat, 0g protein, and 130 calories.

(values found at https://www.carbmanager.com/)

For a more detailed list of Valentine’s candies and their carb counts, thank you to our friends at Waltzing the Dragon for this Valentine Treat Carb Guide (https://waltzingthedragon.ca/diabetes/nutrition-excercise/valentines-day-candy-chocolate-carb-counting-tips/)

Novo Nordisk and Vancouver-based Aspect Biosystems announce a new phase of their partnership

On January 20, 2026 Novo Nordisk (“Novo”) and Vancouver-based Aspect Biosystems (“Aspect”), announced a new phase of their partnership focused on developing curative cell therapies for type 1 diabetes (T1D).

Since 2023, Aspect and Novo have worked together on technologies aimed at producing insulin-secreting islet cells from stem cells. Under the revised partnership, Aspect has acquired Novo’s stem cell–derived islet and hypoimmune cell engineering technologies—designed to create insulin producing cells that can evade immune attack after transplantation into people with T1D.

Novo will continue to invest in Aspect and provide research funding, and it will retain future commercialization and royalty options. This agreement follows Novo’s October 2025 decision to discontinue its cell therapy research and development, including but not limited to, T1D islet manufacturing. As part of the transition, T1D-related research, development, and manufacturing activities will move from the U.S. and Denmark into Aspect’s Canadian platform, expanding the company’s domestic capacity.

This milestone further strengthens Canada’s leadership in T1D research and builds on the $73M Federal–Provincial (BC) investment in Aspect announced in July 2024.

What is Breakthrough T1D’s involvement?

On January 8, 2026 Aspect raised $115M in Series B funding, including from the T1D Fund – A Breakthrough T1D Venture.

Aspect also previously held a Breakthrough T1D International grant (then known as JDRF International) in 2022 to support Aspect’s development of bioengineered tissues that will provide insulin independence and control of blood glucose without the need for chronic immune suppression. In addition to the funding, Breakthrough T1D also contributed strategic support through its vast network in the T1D research field.

What does this mean for Canadians with T1D?
To cure T1D, we need to do two things: we need to protect insulin-producing beta cells from autoimmune attack, and we need to protect and restore their function. To achieve this requires developing a renewable source of cells, as well as therapies that don’t require immunosuppression, as with traditional organ and tissue transplants.

This partnership will help advance cure research that is advancing on both fronts towards the ultimate goal of freedom from insulin, for people of all ages with T1D. And it will be taking place right here in Canada.

Faces of the $100M Campaign to Accelerate: Ramya’s story 

Ramya (left), Dr. Bruce Verchere, Co-Director at the Centre (middle), and Dr. Benjamin Mammon, another member of the T1D Lived Experience Advisory Group (right). Photo credit: Macy Yap

Type 1 diabetes stories help shape research 

Ramya Hosak was diagnosed with type 1 diabetes (T1D) at age 19 while attending university. Since then, she has been a devoted volunteer, helping others navigate the challenges of T1D and the steep learning curve that accompanies a life-altering diagnosis. 

As co-chair of the T1D Lived Experience Advisory Group at the Breakthrough T1D Canucks For Kids Fund Centre of Excellence at the University of British Columbia (UBC), her perspective helps guide the Centre’s research and connect the T1D community with the researchers advancing cures. Her voice is just one of many representing a diverse group of faces and stories, working with researchers to drive innovative therapies.  

Ramya’s passion is nonprofit work, specifically in social justice, community development, and equal access to healthcare. To better unite the T1D community in BC, she co-founded Young and T1, a local support group that helps young adults with T1D through the transition to adulthood. 

We asked Ramya to share the reasons behind her incredible volunteering and what T1D research means to her. 

Breakthrough T1D Canada: Can you tell us about your T1D diagnosis? 

Ramya: I was diagnosed in my second year of university. Super tired and barely able to keep my eyes open in the lecture hall, I was constantly chastising myself. “Don’t be a wimp, everyone else is struggling with midterms and finals, get it together and toughen up, Ramya,” I thought to myself as I chugged a litre of juice. 

But I kept getting weaker. Eventually, my parents dragged me to the hospital, practically carrying me to the ER. That’s when I found out, at 19 years old, that T1D can occur at any age, not just in childhood. Initially, I was relieved at the diagnosis that explained my recent exhaustion. Yet as time went on, questions arose that couldn’t be answered by medical professionals who hadn’t been in my position. My parents and friends assumed that as a responsible adult, I had things under control and was fine. 

But I wasn’t fine. I went from being a student who enjoyed an active social life, going out with my friends without a second thought, to suddenly having to be so careful. I felt a need to act like everything was fine and hide the toll that the invisible full-time job of T1D was having on me, mentally and emotionally.  

I stopped reaching out to my friends for fear of being seen as a complainer and not having a positive attitude. I went through a period of extreme depression, feeling like no one “got me.” But after graduating from university, I started getting better and began meeting others my age with T1D.  

Breakthrough T1D Canada: What drew you to participate in the Centre’s T1D Lived Experience Advisory Group? 

Ramya:  My undergraduate degree was in Health Sciences, and research has always held an interest for me, particularly as my mom is a cancer researcher. I’ve grown up hearing about her excitement, disappointments, and long days/nights that come along with being a researcher. I respect this work immensely, and to be able to work with researchers who are working so hard to find a cure for diabetes and bridge the gap for those living with T1D has always been very important to me. Similarly, I love the questions researchers ask me about living with T1D and helping them to understand why their hard work truly matters.  

Photo credit: Macy Yap

Breakthrough T1D Canada: How do you feel about the cure research happening at the Centre? 

Ramya:  Excited! Not just for me, but for the future generation! I truly believe a cure is in sight, and having had my first child recently (September 2025), the potential to eliminate T1D in the generations to come is such a wonderful thought.  

Breakthrough T1D Canada: What research excites you most? 

Ramya:  I find Dr. Megan Levings’ work on immune system regulation as it relates to T1D particularly interesting. I work at the Kidney Foundation of Canada and have seen her work in the transplant field come up as well. It’s exciting to see research in immunology having the potential to lead to additional breakthroughs in other health-related issues. 

Breakthrough T1D Canada: What are your hopes for the future of diabetes? 

Ramya:  My hope is that within the next generation, T1D markers can be identified in at-risk patients before disease onset or at early onset, and the correct therapies can indefinitely prevent it from fully taking place (by preserving remaining beta cell function, etc.).

“The real glory would be never having to carb-count, constantly be checking my blood levels and worrying about how every variable of life impacts my glucose numbers and therefore how I feel physically and emotionally throughout the day with this 24/7 invisible job. So much mental space would be freed up.”

Ramya with her husband, Mark, who also lives with T1D (diagnosed at age 10), and their newborn daughter. 

Breakthrough T1D Canada: What prompted you to launch Young and T1

Ramya: Upon diagnosis, I started volunteering for Breakthrough T1D (then JDRF), and when working with youth ambassadors, it was so amazing to hear kids meet other kids who shared the same diagnosis. They told stories of bullying at school when their pumps were seen as strange, compared pump colours with each other, and it was just so normal. 

I really wanted a community that “got” what living with T1D in adulthood felt like. T1D gets lonely. I hear this a lot. Young people at this transition stage often feel uncomfortable speaking with their doctor or parents about complex issues that arise for an adult with T1D. Thirteen years ago, I did not realize what an awesome resource Young and T1 would be—for myself and now over 700 individuals in BC—for learning and sharing with one another.  

Through meeting folks with similar daily struggles, and living with my husband Mark, who also has T1D, I have learned that all bodies are different. One size does not fit all in T1D management, and getting as much information available to us as possible is important. By conveying our struggles and successes with one another, we all benefit from shared knowledge. 

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Breakthrough T1D Canada is grateful to Ramya for sharing her story and helping our researchers accelerate breakthroughs. Knowledge sharing is critically important not just among the T1D community but also among the researchers who will one day bring cures to the community.  

Breakthrough T1D oversees T1D research worldwide to ensure that teams are collaborating and sharing learnings. The Breakthrough T1D Canucks For Kids Fund Centre of Excellence at UBC is a prime example of that collaboration in action, with over 40 multidisciplinary researchers working together to tackle all angles of cure research.  

The Centre is a key pillar of our $100M Campaign to Accelerate, a national campaign with a global impact. Read about research highlights from year 4 of the Centre’s three interconnected research themes advancing cures here

Philanthropic donors are advancing promising cure research in BC and around the world. To learn more about these exciting projects or to make a leadership gift, please contact: 

Kim Lacombe, Chief Development Officer 

Cell therapy trial: Encellin’s device delivers promising early results

On January 6th, 2026, Encellin (California, Quebec) reported positive interim results of its Phase 1 clinical trial of encapsulated islets in people with type 1 diabetes (T1D), which is being carried out in Toronto and Montreal.

Trial Details:
In Encellin’s trial, cadaveric human donor islets are being encapsulated in Encellin’s Encapsulated Cell Replacement Therapy (ENCRT) device and implanted into adults with T1D. This first-in-human trial is assessing (1) safety and adverse events, (2) cell survival within the device, and (3) fibrosis, or scarring, around the implants. 

Interim Results:
As planned, ENCRT devices were removed from the initial five participants after 4 months of implantation. Analysis of the removed devices show:

  • minimal to no fibrosis (formation of scar tissue around the device);
  • robust formation of blood vessels around the device;
  • viable islets inside the device.

These results indicate that the device has the potential to host islet cells while maintaining sufficient oxygen and nutrient flow for the cells to work effectively.

Historically, macroencapsulation devices (which act like a teabag to enclose the islet cells) have had limited success due to high levels of fibrosis that prevents cell survival, reduces the ability of the cells to access oxygen and nutrients, and limits the release of insulin. The preliminary finding that fibrosis is not occurring with Encellin’s device is therefore a critical step toward overcoming the barrier of fibrosis with islet encapsulation devices and advancing the development and delivery of cell-based therapies for people with T1D.

We will continue to report updated results as they become available.

Breakthrough T1D’s Role:
Encellin’s technology was originally developed within the Lab of Dr. Tejal Desai (University of California San Francisco) with funding from Breakthrough T1D, which was crucial in the formation of Encellin as a company and attracting subsequent venture capital.

2025 Year in Review

While we look forward to the year ahead, we want to also reflect on 2025 and the breakthroughs we saw, in type 1 diabetes (T1D) research, advocacy, community engagement, and more.  We were also able to host successful events and community initiatives across the country.

Our first full year as Breakthrough T1D Canada was one of impact. And while we may have a new name, our mission and commitment to the T1D community didn’t change; it was only strengthened.

Our incredible community of donors, volunteers, and supporters are the heart and soul of everything we do, and thanks to them it was a transformative year. We committed substantive funding to research, further developed partnerships in academia with new fellowships and grants, continued to support newly-diagnosed people, and our adult T1D community, reinforcing our commitment to being a source of trusted information and support to all Canadians affected by T1D, at any age and any stage of their journey with this chronic disease.

Curing T1D is and remains our north star, while we work to improve the lives today of the estimated 300,000 Canadians with T1D until we have a world free from type 1 diabetes.

Just a few highlights of 2025 included: 

T1D research highlights 

In cell therapies: 

In disease-modifying therapies: 

  • Interim results presented from Sanofi’s PETITE-T1D trial demonstrated acceptable safety of Tzield in kids aged 0-7 with early-stage T1D
  • SAB BIO presented compelling data about humanized anti-thymocyte globulin (ATG), which holds promise to delay the onset and progression of T1D

Improving lives research and mental health supports

In screening: 

  • Continued work by CanScreen T1D, a Canadian T1D screening research consortium led by Dr. Diane Wherrett.  
  • Breakthrough T1D continues to help facilitate screening for relatives of those with T1D across Canada via TrialNet.

For a listing of currently recruiting clinical trials, please visit clinicaltrials.breakthroughT1D.ca

To read more about research updates and stories of people living with T1D, please visit www.breakthrought1d.ca/blog

As we head into 2026, we pause and reflect on how truly grateful we are for the support of our donors, volunteers and the commitment of the T1D community. We’re very excited to approach this new year with renewed vigour, working to build on these breakthroughs and continuing to push our mission forward.  

And thanks to your generosity, cures have never been closer. 

Breakthrough T1D leads publication of Continuous Ketone Monitoring guidance 

In recent years, rapid technological innovations related to diabetes devices like insulin pumps and continuous glucose monitors have significantly helped many people manage their T1D. An exciting new development is underway into continuous ketone monitors (CKM), and Breakthrough T1D is both funding research in this area and shaping recommendations for how they could be used.

On December 9th, a publication on consensus recommendations for the use of CKMs – led by Breakthrough T1D International’s Medical Affairs team – was published in The Lancet. These recommendations and further research and development of these monitors will soon give those with T1D another valuable tool to manage the condition.

What are ketones?

Ketones are organic compounds (acids) that the body makes as a by-product of using fat instead of glucose for energy. This process is called ketosis. A small number of ketones in the body is not concerning, but if they start to build up it can be life threatening. In people with T1D, this may happen because of too little insulin, illness like the flu, prolonged fasting, dehydration or the use of some medications (namely SGLT2 inhibitors). In T1D, a build up of ketones can lead to a serious condition called diabetic ketoacidosis (DKA). 

Learn more about ketones and DKA

Why monitor ketones?

People living with type 1 diabetes (T1D) are familiar with ketones and the risk they present to their health, but monitoring for ketones is burdensome and infrequent for many.

Currently, people with diabetes use blood and/or urine strips to test for ketones; however, surveys show that few individuals use them routinely. Given the current options, it remains very difficult to predict when ketone levels may be rising, and people lose opportunities to intervene early to prevent DKA altogether and could therefore benefit from more routine monitoring.

Similar to continuous glucose monitors (CGMs), CKMs will continuously measure ketone levels in the body and can alert users if their ketone levels are rising. This ability to track ketone levels in real-time could have substantial benefits in preventing DKA—and more. Continuous ketone monitoring (CKM) is on the horizon, but recommendations for use of these devices is lacking.

Potential benefits of CKM for people with T1D 

  • Early detection of rising ketones to prevent DKA 
  • Identification of elevated ketones due to infusion set failures that would prevent pumps from dosing insulin 
  • Valuable addition to automated insulin delivery (AID) systems for comprehensive monitoring of blood glucose and ketones 
  • Management of early-stage T1D—before insulin therapy is needed—to monitor disease progression  

Recommendations for use of CKM

CKMs have the potential to transform T1D care by stopping dangerous, life-threatening DKA before it ever occurs. It is critically important that healthcare professionals (HCPs) and people living with T1D know how to most effectively use this technology to maximize its benefits.  

That’s why Breakthrough T1D International, led by their Chief Medical Officer Thomas Danne, convened a panel of experts to agree on recommendations for how this technology could be used to improve outcomes for individuals at risk for developing diabetic ketoacidosis (DKA). 

The recommendations from the expert panel are: 

  • CKMs could include trend arrows, akin to those on a Continuous Glucose Monitor (CGM), and reflect rates of change of around 0.4 mmol/L per hour. 
  • To avoid potential alarm fatigue, CKM devices should have optional individual alarms and be used at the discretion of the user and their health-care professional 
  • It is recommended that an audible or vibrating alarm should be put in place to notify continuous ketone monitoring users if their ketone concentrations rise above the urgent high threshold of ≥3·0 mmol/L. 
  • The terminology for ketone levels should be: Normal, Elevated, High, Urgent High. 
  • All CKM users should be provided with a blood ketone metre to use if they are experiencing the symptoms of high or urgent high ketones, and they do not match the CKM reading.  
  • All individuals who wear a CKM should receive education on what elevated ketones mean and what actions to take.  

Why might this matter to you?

There are currently no continuous ketone monitors available on the market, but Breakthrough T1D is actively funding work in Canada and globally to make these a reality. Both academic groups and early-stage companies are working on CKM devices. Further down the pipeline is Abbott’s dual glucose-ketone sensor (CGM-CKM), which is currently in development. Including in Canada with Dr. Mahla Poudineh (University of Waterloo), in collaboration with Dr. Leyla Soleymani (McMaster University) who are also working on developing a wearable CKM.

Breakthrough T1D’s work in this area – funding research and developing recommendations for CKM use is crucial as they will be a reality soon and both healthcare providers, people with T1D and their caregivers will need standards on how to use these devices to be able to take action before DKA occurs.  

Breakthrough T1D Canada will keep the community up to date on the progress of CKM development. For clinical trials that may be testing these devices and others, visit clinicaltrials.breakthroughT1D.ca

Updates on recent type 1 diabetes clinical trials

In addition to funding research, a key component of Breakthrough T1D’s research strategy is the promotion and knowledge translation of clinical trials. Here we report on recent results from international trials relevant to our type 1 diabetes (T1D) community.

To see if there is actively recruiting research that you can be part of, see our T1D Clinical Trial Finder.

Cell Therapy: Tegoprubart trial
Current islet transplantation (from cadaveric donor islets in clinical practice to stem cell derived islets in clinical trials) require immunosuppression to protect the islets from the recipients’ immune system. Dr. Piotr Witkowski (University of Chicago) is investigating the use of tegoprubart as a less toxic alternative to commonly used tacrolimus for people with T1D receiving cadaveric donor islet transplants.

Tegoprubart (AT-1501) is an anti-CD40L antibody owned by Eledon Pharmaceuticals and has shown promising safety and efficacy data for kidney transplants.

In the ongoing islet replacement trial, preliminary data on the first six subjects show that tegoprubart is able to protect the transplanted cadaveric donor islet cells. All six transplanted subjects demonstrated marked improvements in glycemic control, achieving and maintaining insulin independence after one or two islet transplants.

Tegoprubart was generally well tolerated, with no reported serious adverse events and no signs of the kidney or neurological toxicity often observed with traditional immunosuppression.

This clinical trial is partly funded by Breakthrough T1D International and Eledon Pharmaceuticals is funded by the Breakthrough T1D Fund.

Disease-modifying therapy: PETITE-T1D
Disease-modifying therapies address the underlying cause of T1D, meaning that they protect beta cells, stop the autoimmune attack, or both.

Sanofi’s PETITE-T1D trial is testing the efficacy and safety of Tzield in kids aged 0-7 with early-stage T1D.  Tzield is currently approved by Health Canada for children and adults aged eight and older with stage 2 T1D, in whom it can delay the onset of stage 3 T1D by a median of 3 years.

Interim results from PETITE-T1D show that the safety profile of Tzield in children under the age of 8 is similar to that of older individuals who receive the drug. This study is ongoing, and we look forward to seeing efficacy data (how well it is reducing the autoimmune attack) in 2026.

Disease-modifying therapy: TrialNet Abatacept Prevention Study
New analysis from TrialNet on abatacept’s impact on type 1 diabetes progression suggest that further investigation may be warranted.

Abatacept (brand name Orencia®) is a prescription biologic medication that is used to treat certain autoimmune diseases. It works by blocking the activation of T-cells, a type of immune cell that causes inflammation,

The Abatacept Prevention Study first opened in 2013 and enrolled 212 people between the ages of 6 and 45. All participants had at least one relative with T1D and were identified as being Stage 1 T1D (which means they had two or more diabetes-related autoantibodies but normal glucose tolerance).

The initial study analysis found that while abatacept impacted immune response and preserved insulin production during the one-year treatment period, it did not meet the study goal of delaying progression to abnormal glucose tolerance (stage 2 T1D) or clinical diagnosis of T1D (stage 3 T1D). The group treated with abatacept maintained beta cell function better than the placebo group at 12 months. In addition, known effects of abatacept were detected on immune cells. However, 12 months after treatment ended, beta cell function was the same for both groups and effects on immune cells had reversed. The early effect was not sustained.

In a re-analysis of the data, it was found that the participants who were secreting the most insulin at the start of the trial had the most benefit from Abatacept. This is the first indication that an immune intervention in stage 1 T1D may delay disease progression in a subset of individuals. As studies into disease-modifying therapies sig deeper into why certain people respond better than others, it is becoming clear that a precision medicine approach will be needed to get people the most beneficial therapy possible.

Kidney complications: Finerenone
In November 2025 Bayer shared data from the international phase 3 clinical trial (FINE-ONE) which included participating sites across Canada. These results showed that finerenone (Kerendia™/Firialta™) significantly reduces urine albumin-to-creatinine ratio, a measure of kidney damage, in people with chronic kidney disease (CKD) associated with T1D.

In CKD, the hormone aldolsterone is overactive, leading to kidney damage. Finerenone blocks this hormone’s activity to protect the kidneys from further damage. Finerenone has already been approved for the treatment of CKD in type 2 diabetes.

Finerenone was well-tolerated, with no new safety issues reported and few serious adverse events. Based on these results, Bayer intends to submit the data for regulatory review, with the goal of expanding finerenone’s indication to include treatment of CKD in people living with T1D.

CKD is one of the most common complications of T1D. Nearly a third of people living with T1D will develop CKD, increasing the risk of both kidney failure and cardiovascular disease.

Finerenone is the first therapy in three decades to achieve positive outcomes for CKD in people with T1D.

Breakthrough T1D strategically collaborated with Bayer to support the FINE-ONE clinical trial.

Devices in Pregnancy: CIRCUIT Trial
To assess the efficacy of a closed-loop system in pregnancy, a randomized clinical trial in Canada and Australia, enrolled pregnant women with T1D before 14 weeks’ gestation, with follow-up until 6 weeks postpartum.

They analyzed 88 participants who were randomly assigned by 16 weeks’ gestation to closed-loop therapy or standard care. The standard care group continued their pre-randomization insulin delivery method (multiple daily injections or insulin pump), and all participants used continuous glucose monitoring throughout the study.

The mean percentage of time in the pregnancy-specific glucose range was significantly higher in the closed-loop group (65.4% TIR) than in the standard care group (50.3% TIR); the adjusted mean glucose level was also lower in the closed-loop group than in the standard care group.

The findings support the use of closed-loop systems in pregnancy with T1D.

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Breakthrough T1D Canada will continue to monitor the results of these trials and share more updates as they become available.

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